Double-pulse facilitation of smooth muscle alpha 1-subunit Ca2+ channels expressed in CHO cells.
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چکیده
منابع مشابه
Ca2+ entry channels involved in endothelin-1-induced contractions of vascular smooth muscle cells.
Endothelin-1 (ET-1) is a 21-amino-acid peptide and it is one of the most potent endogenous vasoconstricting agent yet discovered (Yanagisawa et al., 1988). ET-1 binds to its receptors (typically ETA receptor) on vascular smooth muscle cells (VSMCs) and subsequently induces an increase in the intracellular free Ca2+ concentration ([Ca]i), which is essential for contraction of the cells. It is ge...
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The effects of sulfhydryl reduction/oxidation on the gating of large-conductance, Ca 2 1 -activated K 1 (maxi-K) channels were examined in excised patches from tracheal myocytes. Channel activity was modified by sulfhydryl redox agents applied to the cytosolic surface, but not the extracellular surface, of membrane patches. Sulfhydryl reducing agents dithiothreitol, b -mercaptoethanol, and GSH ...
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Carbon monoxide (CO) is a gaseous vasodilator produced by many cell types, including endothelial and smooth muscle cells. The goal of the present study was to investigate signaling mechanisms responsible for CO activation of large-conductance Ca(2+)-activated K(+) (K(Ca)) channels in newborn porcine cerebral arteriole smooth muscle cells. In intact cells at 0 mV, CO (3 microM) or CO released fr...
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Ca(2+) influx across plasma membranes may trigger Ca(2+) release by activating ryanodine-sensitive receptors in the sarcoplasmic reticulum. This process is called Ca(2+)-induced Ca(2+) release, and may be important in regulating cytosolic Ca(2+) concentration ([Ca(2+)](i)). In cardiac cells, the initial [Ca(2+)](i) increase, caused by L-type Ca(2+) current, is profoundly amplified with Ca(2+) r...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1994
ISSN: 0261-4189
DOI: 10.1002/j.1460-2075.1994.tb06538.x